Anime director Hiroshi Nagahama (Mushishi, Flowers of Evil, Detroit Metal City, The Reflection) stated at the "Hiroshi Nagahama – Past and Future" panel at Sakura-Con on Sunday that his next project will air in North America first. He added that a U.S. company approached him for the project. Nagahama did not give any other details about the project.
Nagahama also stated during the "Hiroshi Nagahama – Working with Stan Lee" panel on Friday at Sakura-Con that he would like to continue the universe he and Stan Lee created for the The Reflection anime project. He added that the first anime only showed part of that universe.
Nagahama had said at Tokyo Comic Con in December 2017 about The Reflection, "We are trying to make a sequel. We will do it!" He added at the time that he thought Lee would make an announcement for it at a later date. Lee then passed away in November 2018 at age 95.
Studio DEEN collaborated with Lee (Spider-Man, X-Men, Heroman) and his Pow! Entertainment company for the project. Lee is credited with the original work, and Pow! Entertainment and Studio DEEN are credited with the project planning. Nagahama co-created and directed the series at Studio DEEN, and he also provided the original character designs.
Sources: "Hiroshi Nagahama – Working with Stan Lee" and "Hiroshi Nagahama – Past and Future" panels at Sakura-Con